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This shift may be attributed to the previously documented gut microbiome alteration in FM subjects 15,38,39,40 or due to an increased intestinal permeability observed in FM subjects 41,42

Dong L, Lu D, Chen R, Lin Y, Zhu H, Zhang Z, et al

doi: 10.1016/s0092-8674(03)00154-5

In its inactive state, ASK1 binds to reduced thioredoxin (TRX), which can be oxidized by H 2 O 2 , resulting in the dissociation and subsequent activation of ASK1