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The carefully designed vaccine platform not only achieves precise spatiotemporal targeted delivery of the vaccine, but also has the function of modulating the immunosuppressive TME, thereby inducing a strong tumor antigen-specific response (Zhang et al., 2021)

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The animals were anesthetized by inhalation route with Isofluorane (Isboa Vet) using a vaporizer and intranasal administration was performed with two instillations of 20 l of the bacterial suspension prepared in PBS