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Vitamin B12 prevents the loss of neurons in the brain, helping to improve brain function and prevent memory reduction

However, limitations exist in the form of in vivo instability, the reliance on carriers that are biocompatible and robust and limited sites of application (local and direct) (Park et al

To assess the independent role of B 12 on outcome variables, multivariate linear regression was carried out, adjusting for all possible confounders including age and BMI as independent variables

Despite this low level of expression, reduced Tbx1 dosage in adult heterozygous mice leads to mild brain vessel hyperbranching and disorganization of the entire brain vessel network, as well as reduced brain vessel perfusion, and tissue hypoxia (38)