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The advancement of kidney-targeted drug delivery systems utilizing low-molecular-weight proteins and chitosan is a promising strategy for targeting proximal tubular and mesangial cells, which are ideal for particulate drug delivery systems such as nanoparticles or liposomes [75]

The toxicity of nanoparticles is related to various factors such as route of administration, ingested dose, surface modification, particle size, shape, polydispersity coefficient, and others (Teleanu et al., 2018