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Laboratory research has established FOXO4-DRI as an invaluable tool for investigating fundamental questions in aging biology, regenerative medicine, cancer research, and tissue engineering, with its proven efficacy across diverse experimental models enabling researchers to test causal relationships between senescence and age-related phenotypes

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[43] Embryotoxic and teratogenic effects (syndactylia and oligodactylia) have been demonstrated in animals receiving oral ketoconazole doses at 10-times the maximum recommended human dose