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Overall, these studies highlight the role of adipocyte lipolysis in inter-organ crosstalk through the release of lipid signals and EVs to regulate whole body tissue homeostasis (Figure 4)

In fact, about 65% to 82% of people will have injection site pain with the COVID vaccine, and more specifically, if youve gotten the Moderna shot

doi: 10.3389/fimmu.2026.1769281 Received 16 December 2025 Revised 08 April 2026 Accepted 13 April 2026 Published 29 April 2026 Volume 17 - 2026 Edited by Douglas Sborov, The University of Utah, United States Reviewed by Nomie Leblay, University of Calgary, Canada Xuan Jiang, Shanghai Jiao Tong University, China Updates Copyright 2026 Horenstein, Frerichs, Faini, van de Donk and Malavasi