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A blockage of ascorbate accumulation in response to high light was also observed when glutathione deficiency was induced pharmacologically by buthionine sulfoximine treatment, providing extra evidence that, in high-light conditions, glutathione acts as a substitute for ascorbate reduction (Figure 1)

This leads to the development of malignant tumors, like hepatocellular carcinoma (HCC) (Gerdemann et al

Mitochondrial oxidative stress causes mitochondrial fragmentation via differential modulation of mitochondrial fission-fusion proteins

Useckaite and colleagues in year 2020, examined the content of EVs from CF bronchial epithelial cells (CFBE41o-) and found that these vesicles were notably enriched with proteins linked to acute inflammatory stress and infection in CF lung disease [6]