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If GSH peroxidase activity is deficient, lipid peroxidation could increase in the tissues, leading to increased stimulation of PGH synthase, increased thromboxane production, and further increase lipid peroxides

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For thiol oxidations to be consequential inside cellsfor example, to inactivate an enzyme population to the extent that a pathway bottleneck arisesthe rate of thiol oxidation must be fast, with a majority of enzyme molecules being oxidized within a cell generation