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Finally, skatole could reduce TCDD-induced CYP1A1 expression, suggesting that skatole is a partial AhR agonist

By inhibiting the transcriptional activation of monocarboxylate transporter 1 (MCT1) and lactate dehydrogenase B (LDHB), BACH1 impedes lactatemediated mitochondrial metabolism

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However, relationships between brain GSH levels, which are representative of OS, and cognitive function, have not been found in healthy participants 11,12