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A randomized, placebo controlled, multicenter study to evaluate the safety and efficacy of rofecoxib in the treatment of chronic nonbacterial prostatitis

However, at 25 times the human dose, fetal malformations were not observed

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The qRT-PCR analysis of mRNA expression revealed the upregulation of genes associated with antioxidant defense (SIRT1, Nrf2, HO-1, NQO1) along with the downregulation of the apoptotic markers caspase-8 and 3, respectively