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They employed PRS and whole-genome sequencing (WGS) to investigate the impact of rare variants, uncovering the critical roles of BAG3 and TTN genes (47)

2 for full blot images)

Though non-specific, certain pathogenic factors including genetic predisposition, visceral hypersensitivity, food intolerance, altered gut-brain axis and gut dysmotility, dysfunction of innate immunity and dysbiosis may contribute to this disorder (Figure 1)