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While studies have already revealed that in patients with HER2-positive breast cancer, some metastases can be prevented with existing HER2-targeted treatments, many areas of investigation remain: Identifying and treating drivers of resistance in advanced HR-positive/HER2-positive breast cancers Focusing on how the tumor interacts with nearby immune cells to influence HER2-positive metastatic breast cancer formation Developing complex HER2-positive metastatic breast cancer models to test the next generation of cancer immunotherapies and predict tumor response to therapy Conducting a clinical trial in patients with HR-positive/HER2-enriched metastatic breast cancer to see if androgen receptor-inhibiting drugs can improve treatment response in these patients