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Description

Mechanistically, icaritin is an inhibitory-B Kinase alpha (IKK-) inhibitor, which inhibits the NF-B signaling pathway by blocking IKK complex formation, and further dose-dependently downregulates PD-L1 [216]

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LPBNAH is another spin trap derivative

P-glycoprotein (P-gp) P-gp is a membrane-associated pump that actively transports a variety of drugs from the cells by utilizing the energy generated from ATP hydrolysis, which favors the development of the so-called multidrug resistance (MDR) in normal and diseased tissues, including cancer