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intravenous (some studies) Protocol: Cyclic -- 5-10 mg/day for 10-20 consecutive days, repeated every 4-6 months (2-3 cycles per year) Rationale: Brief telomerase activation extends telomeres, which then provide sustained replicative capacity during drug-free intervals Requirements: Sterile reconstitution, cold chain storage, injection supplies, injection technique Regulatory status: FDA Category 2 since 2024 (banned from compounding in the US) NAD+# Route: Oral (NMN, NR supplements)

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This balanced inflammatory modulation prevents the chronic inflammation associated with impaired healing in diabetic or venous insufficiency ulcers, while avoiding excessive immunosuppression that could increase infection risks

Furthermore, numerous virulence factors in H