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This is why you find it in all sorts of cosmetic actives serums, creams, lotions, ampoules in concentrations appropriate for stability and safety

Disorders of collagen biosynthesis and structure

MSCs exert their therapeutic effects on PNI possibly through their dual functions, multipotent differentiation capacity into neural type of cells and their paracrine secretion of an array of bioactive factors with multiple trophic effects on both neural and nonneural cells [13], whereby the potent immunomodulatory effects of MSCs on immune cells, particularly macrophages, may constitute one of the major mechanisms by which MSCs exert their therapeutic effects on PNI [14]

Furthermore, during cellular uptake and metabolic absorption, EVs themselves degrade quickly or are actively cleared by the body, leading to a high degradation rate (Tran et al., 2020)