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10.1016/S2468-1253(17)30338-2 Lancet Gastroenterol

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Although the CFTR KO mouse utilized in this study does not develop spontaneous lung disease, it is an ideal model system to examine the effects of CFTR transport deficiency without the confounding effects of lung damage and excess inflammation

Transient increases in maternal cytokines, including IL-6 and IL-17, can cross the placental barrier, leading to immune stress in the fetal brain and affecting the development and function of microglia and astrocytes (Smith et al., 2007