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Here, we review the mechanism of action of cisplatin, the mechanism of resistance to cisplatin, the role of metabolic remodelling in tumorigenesis and development, and the effects of common metabolic pathways on cisplatin resistance

Experiments are in compliance with the ARRIVE guidelines ( Expression and purification of recombinant oIGF-1 The recombinant oIGF-1-N-terminal-protease (NPro) fusion protein coding sequence was cloned into pD451-SR plasmid under T7 promoter and transformed into E