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In sickle cell disease and thalassemia, sustained Ca 2+ influx activates scramblases and inhibits flippases, resulting in chronic phosphatidylserine exposure, procoagulant activity, and increased RBC clearance (24, 45)

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We refer the reader to the ICD-10 MS-DRG Version 40.1 Definitions Manual (which is available on the CMS website at: ) for complete documentation of the GROUPER logic for the listed MS-DRGs

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