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A portion of pyruvate enters the mitochondria where it is used to fuel energy production via the citric acid cycle and oxidative phosphorylation (OXPHOS)

Jiang, L

However, it is unclear whether NCOA4 can bind to the cell membrane before translocating to the cytoplasm, apart from the evidence demonstrating its truncated isoform SRC3s ability to bind to the cell membrane [44]