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Similarly, targeting NRF2 to upregulate phosphorylase kinase catalytic subunit 2 promotes ferritinophagy and mitochondrial stress-dependent ferroptosis, increasing radiosensitivity (123)

A 2008, 112, 9037-9042

MTs bind up to seven zinc ions per molecule via thiolate clusters formed by their 20 cysteine residues, exhibiting high thermodynamic stability and kinetic lability, enabling rapid zinc exchange