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366 PI3K subunit KO in mice or treatment with a PI3K inhibitor markedly aggravated hepatocyte necrosis and inhibited liver regeneration

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Furthermore, oxidative stress can induce damage to DNA, which is particularly concerning in the context of carcinogenesis

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Week 6-8: Resolution of most acute muscular issues

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The immunopathogenesis is driven by a predominance of T helper (Th)1-mediated immune responses, with elevated interferon- (IFN-) production and impaired function of regulatory T cells (Tregs), which normally restrain autoreactive lymphocytes [11,12]

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