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Dendrite length was determined using the National Institutes of Health's Image J 1.41o program (NIH, Bethesda, MD) and the neurite tracing program Neuron J (Meijering et al., 2004) Spines were manually counted

This concern is particularly relevant with aggressive caloric deficits, and cagrilintide's appetite-suppressing effects can create substantial caloric deficits

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Contrasting Preclinical Promise with Human Data The central challenge for clinicians is the stark contrast between the vast, overwhelmingly positive body of preclinical BPC-157 evidence and the near-total absence of published, peer-reviewed human clinical trials