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Description

The chaperone Hsp90: changing partners for demanding clients

Compound: BPC-157 at 200 to 300 micrograms per day, split into two administrations (morning and evening)

Initially, the IU/JAX/PITT group created mice that are double homozygous for APOE4 and Trem2 R47H (termed LOAD1) ( APOE4 is the greatest genetic risk factor for LOAD which is thought to increase the risk for AD through both gain and loss of function effects on multiple processes in the brain including amyloid clearance, synaptic plasticity, and cerebrovascular health ( TREM2 R47H is a rare coding mutation with a partial loss of function that alters the behavior of microglia ( via CRISPR/CAS9