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Metformin-induced AMPK activation significantly improved renal autophagy, inhibited EMT of renal TECs, reduced tubulointerstitial fibrosis and delayed the onset of DKD (144)

Because almost all controlled research to date has been conducted in rodent models, intellectual honesty requires treating the human implications as promising extrapolations rather than established clinical fact

Zhang Y, Yang X, Wang S, Song S (2019) Ginsenoside Rg3 prevents cognitive impairment by improving mitochondrial dysfunction in the rat model of Alzheimers disease

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