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also allow for easy dosing

To investigate this, we depleted platelets in C57Bl/6 J mice by injecting 2 mg/kg anti-CD41 antibody or IgG control 12 and 2 h before a moderate (300 mg/kg) or severe (600 mg/kg) APAP overdose

Science 270 , 5051 (1995)

Later in the review, we look for supporting evidence for metabolic pathway dysfunction, identified by serum and plasma metabolomics, by examining proteomics analysis of biological material and whole patient imaging studies