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The scRNA-seq results showed that the expression of YAP/TAZ target genes, which play a central role in mechano-stress responses, was upregulated in LSECs in the pIVCL group, and that connective tissue growth factor (CTGF) was the most greatly upregulated gene in the whole LSEC population and more upregulated in zone 3 LSECs than in zone 1 LSECs

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The presence of these intensely pruritic epidermal burrows in classic flexural and interdigital distributions is highly characteristic of an infestation with scabies