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Physiology 301 (3), R701R715

Both compounds have attracted clinical interest due to their roles in energy metabolism, cardiovascular health, and potential therapeutic applications in various conditions characterised by mitochondrial dysfunction or energy deficiency

Loss of MCUR1 or MCU activity has also been linked to reduced muscle mass and strength in mouse models, and MCUR1 was found to be downregulated on the mRNA level in older sarcopenic patients, suggesting that both proteins have a role in muscle regeneration [17, 28, 29]

Kersten S, Stienstra R (2017) The role and regulation of the peroxisome proliferator activated receptor alpha in human liver