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57 MitsuishiY.TaguchiK.KawataniY.ShibataT.NukiwaT.AburataniH.et al (2012)

This Polyol (Sorbitol) pathway is activated only if the concentration of glucose in cells is high because the enzyme Aldose reductase has a relatively low affinity for glucose (and conversely high Michaelis Menten constant K m )