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Description

The primary methods use epichlorohydrin as the starting material, differing in whether the chemical resolution is performed at different stages of the reaction or a chiral reagent is introduced before the reaction for asymmetric induction to obtain L-carnitine

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In the cytosol of E

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doi:10.1146/annurev.cellbio.22.010605.093503

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This azobenzene-based design allowed reverse photoregulation of NAMPT activity and downstream NAD + levels, crucially avoiding the off-target toxicity in the dark state that plagues inhibitor-based PS-PROTACs and thereby laying a foundation for clinical applications

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