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Nonspecific effects and long-term toxicity of conventional immunosuppressants underscore the need for more selective, targeted interventions

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It plays a part in regulating inflammatory responses, causing pancreatic cell damage and necrosis, contributing to pancreatic fibrosis, and disrupting normal pancreatic function through effects on mitochondrial function and cellular gene expression

However, this prevalence may be overestimated due to inadequate distinction between pre-existing and treatment-related GHD [18, 24, 25, 27,28,29, 31,32,33, 36, 38, 40,41,42], along with the inclusion of larger registry studies with GHD as an inclusion criterion, leading to a reported 100% prevalence [27, 31, 40]