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In contrast, the PDI ALS-mutants (D292N and R300H) lack this redox activity and were not protective against ALS phenotypes, further confirming the importance of the redox activity of PDI in ALS (Parakh et al., 2020)

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An antibody fragment consisting of a single monomeric variable domain (V H ) naturally occurring in the Camelidae family or synthetically derived from the heavy chain of an antibody, combining high antigen affinity in the absence of complement-dependent or cell-mediated cytotoxicity due to the lack of a constant (Fc) region