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Patients with low-normal or borderline B12 (200400 pg/mL) may experience quicker symptom relief and fewer adverse effects than those with truly deficient levels, who may require supplemental or prescription-grade B12 dosing instead

doi:10.1345/aph.1M176

Myelination and mTOR

On the other hand, there is no such thing as a vitamin B12 overdose, because there is no such thing as a maximum dose for vitamin B12, according to both Tufts University Health & Nutrition Letter and Harvard T.H