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For tirzepatide, clinics should rely on current FDA labeling for: Contraindications Warnings and precautions Use in pregnancy Drug interactions Guidance for patients with certain endocrine histories or GI conditions Monitoring recommendations For AOD 9604, the lack of FDA approved labeling for obesity means clinics have less standardized, label grounded safety direction for that use

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14 Inclusion criteria required a life expectancy of over one month and a baseline serum sodium 2 mg/dL, hypotension, or patients on vasodilators/inotropes)(baseline characteristics above)

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