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This is where the medication starts earning its reputation

If semaglutide (single agonist) is first generation, and tirzepatide and mazdutide (dual agonists) are second generation, then retatrutide (triple agonist) is the beginning of the third generation

Conversely, this review highlights that TDEs also can majorly suppress B cell immunity, acting as antibody decoys, transferring immunosuppressive ligands, such as HLA-G, and possibly pushing B cells toward Bregs which inhibit effector T cells (94)