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Pre-existing conditions such as diabetes, cardiovascular disease, hormone imbalances, liver issues, kidney problems, or autoimmune conditions can influence how the body responds to certain peptides

By analogy with semaglutide (where the STEP-4 withdrawal trial demonstrated substantial weight regain within 12 months of discontinuation), researchers should anticipate that weight regain is likely following cessation of any GLP-1 class compound, including retatrutide

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