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To generate AdipoQ-CreERT2 x p53-Lox mice, female mice heterozygous for the CRE-transgene and homozygous for loxP-flanked allele were bred with male mice homozygous for loxP-flanked allele starting at the age of 10 weeks

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Optimal results require minimum 16-week protocols, ideally extended to 6+ months for comprehensive evaluation

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