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Herein, we found that SLC1A5 and GLS1 inhibition decreased GSH levels and GPX4 activity and improved CRPC cell sensitivity to RSL3-induced ferroptosis, whereas YAP1 increased GSH levels and GPX4 activity in cells by increasing SLC1A5 and GLS1 levels, antagonized ferroptosis in CRPC, and promoted the role of glutamine metabolism in CRPC

In contrast, loosely coupled mitochondria yield less ATP, requiring more substrate and resulting in greater heat dispersion due to proton leakage

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The synergistic effect of combining a GHRH analog with a growth hormone secretagogue creates stronger GH pulses than either peptide achieves independently