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A regulated form of necrosis, known as necroptosis, is a caspase-independent cell death mechanism that displays typical features of necrosis, including morphological alterations, subcellular changes, and metabolic dysfunction

The use of electro-acupuncture to stimulate the Zusanli (ST36) acupoint can activate the 7 nicotinic acetylcholine receptor in the lung tissue through the cervical vagus nerve and sciatic nerve to protect the ferroptosis in the lung tissue, which also verifies the importance of the vagus nerve in protecting the oxidative damage of cells (104) ( Figure 2 )

These results indicate that MA toxicity involves not only classical TCA cycle inhibition but also close association with systemic oxidative stress

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