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Essam RM, Ahmed LA, Abdelsalam RM, et al

By regulating the Nrf2/HO-1 pathway, A5 improves the activity of SOD and GPX and the level of glutathione, reduces the levels of iron deposition, 4-HNE and MDA, thereby improving the ferroptosis of neurons induced by TBI

& Carneiro, G

This prospective, double-blinded, placebo-controlled trial allocated 41 patients into four arms: steroid treatment, steroid placebo, carbogen inhalation, and inhalation placebo