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Phase 2 dose-finding trial (Lancet 2021) showed clear dose-response from 0.3 mg up to 4.5 mg/week, but 2.4 mg is the dose Novo Nordisk advanced into Phase 3 and is the most commonly self-reported community ceiling

In cosmetic dermatology, the data is promising, but not as extensive or long-term as the evidence behind gold-standard ingredients like retinoids or vitamin C, she adds