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Could have systemic side effects

Researchers have investigated how MT-1-mediated MC1R activation may modulate cellular responses to ultraviolet radiation in laboratory models, adding another dimension to the peptide's research utility (Abdel-Malek et al., 2006)

But a 2025 interview study of 29 self-reported users found something else entirely average age 39, more than three in four men, most introduced to it through gym and bodybuilding circles years before any tanning trend existed online

Abstract: Penile melanoticmacules, a benign acquired melanosis generally observed in adulthood, may be present on the shaft of the penis or on the glans penis and can mimic mucosal melanoma