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In comparison, the effects of tesofensine were not significantly different from placebo and were lower than the effects of D-amphetamine 30 mg on both primary and most secondary measures

For example, in animal studies, methylcobalamin significantly prolonged the survival of mice with cancer, while cyanocobalamin was completely ineffective (6)

The mechanisms underlying how Contrave assists with weight loss are not entirely clear, however, the mechanism may be similar to other weight loss drugs