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Inspecting the binding sites, we note that there are three sequence differences that would mostly affect the binding of Ator2

Xu X, Qin Z, Zhang C, Mi X, Zhang C, Zhou F

Additionally, certain antihypertensive and lipid-lowering drugs, such as losartan, simvastatin, atorvastatin, and fenofibrate, have been shown to reduce serum uric acid levels, potentially exhibiting a synergistic effect when used alongside standard hypouricemic treatments