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This leads to an increase in the activity of the glutathione-dependent enzymes, glutathione reductase and glutamate-cysteine ligase, and the glutamate/cystine antiporter, which are critical in the production of reduced glutathione, which plays a vital role in neutralizing ROS (Lee et al., 2003

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Also, a lot of studies have examined the treatment effects of NAC in animal models and human data reporting cognitive improvement in both preclinical and clinical studies in neurodegenerative and neuropsychiatric disease including AD (65), PD (66), stroke (67), depressive and anxiety disorder (68, 69), and mTBI (70)

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Contemporary smart hydrogels go further by responding to multiple endogenous cues (enzymes, reactive oxygen species, pH, temperature) and exogenous cues (light, electricity, magnetism, ultrasound, mechanical force) with spatiotemporal control

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