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Description

HIF-1 expression in healing wounds: HIF-1alpha induction in primary inflammatory cells by TNF-alpha

Whether it accumulates in tissues is unknown

However, no clear pattern was found across treatment days

Although tools such as DdCBE and TALED achieve mitochondrial localization through mitochondria-targeting sequences, accumulating evidence indicates that they can nonetheless induce detectable off-target edits in nuclear DNA [548, 549]