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Contraindications Depakote Sprinkle Capsules should not be administered to patients with hepatic disease or significant hepatic dysfunction [see Warnings and Precautions (5.1)]

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Cytotoxic effects of APE on RAW264.7 cells, human PBMCs, and human PMNs The cytotoxic effects of APE on RAW264.7 macrophage cells and human leukocytes, including peripheral blood mononuclear cells (PBMCs) and polymorphonuclear cells (PMNs), were evaluated following 24 h treatment at various concentrations of APE (250, 500, 1000, 2000, and 4000 g/mL)

J Psychopharmacol 35(12):14641472 Fernndez A, Rodriguez-Palancas A, Lpez-Ibor M et al (2005) Increased occipital delta dipole density in major depressive disorder determined by magnetoencephalography