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547 A comprehensive and multidisciplinary analysis of post-mortem brain tissue in AD patients, including protein immunoblotting, elemental analysis, and metabolomics, showed that iron imbalance and elevated ferritin levels were associated with lipid peroxidation in AD patients

Within the pathological milieu of uremia-associated CKD, the intestinal microbiome undergoes profound compositional dysregulation, manifesting as precipitous depletion of beneficial microbial taxaparticularly short-chain fatty acid (SCFA)-producing genera including Faecalibacterium prausnitzii , Roseburia, Bifidobacterium, and Lactobacillusconcomitant with the aberrant proliferation of opportunistic pathogenic species such as Escherichia coli , Shigella, and Enterococcus (Lyu et al., 2023

Inflammatory responses increase oxidative stress and oxygen free radicals, which impair GAG synthesis

34 days) and higher rates of complete recovery (95% vs