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RahmelTHbnerMKoosBWolfAWillemsenKStrauGet al

In the initial model, brief intracerebroventricular pulsed infusions of propionic acid into adult animals produced reversible (~30 min) bouts of ASD-type behaviors including altered social interactions (193), stereotyped behavior (194), tics (194), and hyperactivity (194, 195) as well as other cognitive and sensorimotor deficits (196) [see Fig