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In vitro, co-culture of GMSCs encapsulated in the 3D-collagen hydrogel with macrophages remarkably increased the secretion of IL-10, an anti-inflammatory cytokine characteristic of pro-regenerative (M2) macrophages, but robustly reduced LPS-stimulated secretion of TNF-1 and IL-1, two cytokines characteristic of pro-inflammatory (M1) macrophages

Additionally, the transcription of genes such as SAT1, HMOX1, and ACSL1, which sensitize cells to ferroptosis, were all increased by JQ1 [45,46,47] (Fig

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Melanocortin agonism stimulates melanocytes, and a related report describes eruptive nevi a sudden crop of new moles associated with an -MSH analog, exactly the kind of pigment-cell proliferation one would predict from over-stimulating this pathway