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Salvianic acid A, the active ingredient of traditional Chinese medicine, can down-regulate the expression of inflammatory factors by inhibiting NF-B/HIF-1 and HIF-1/STAT3/NLRP3 signaling pathways, inhibit cell excessive proliferation, and improve hypoxia-induced FLS injury (154)

Quayle AJ, Porter EM, Nussbaum AA, Wang YM, Brabec C, Yip KP, Mok SC: Gene expression, immunolocalization, and secretion of human defensin-5 in human female reproductive tract

Shelise Edwards, MD, FACEP, is a board-certified emergency medicine physician

Together, these findings suggest that checkpoint activation could indirectly influence ferroptosis-associated pathways in AD, yet the connection remains inferential, underscoring the need for future multi-omics and spatial single-cell studies in human brains to validate this link